VITAMIN D3 10,000

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Dr. Freire's Vitamin D3 10,000 IU supplies cholecalciferol, a highly absorbable and bioavailable form of vitamin D (from lanolin), for optimal nutritional benefits for the skeletal, cardiovascular and immune systems. Vitamin D3 is the naturally occurring form of vitamin D synthesized in humans. Studies show that plant-derived D2 is metabolized differently than D3 and that D3 may be over 3 times more effective than D2 in raising and maintaining serum vitamin D levels.

Vitamin D3 is most noted for optimizing calcium bioavailability, thereby promoting peak bone mass and bone strength. Patient One Vitamin D3 10,000 IU is a professional-strength medinutritional formula that promotes compliance through once-a-day high-potency administration.

D3 10,000 IU:

Patient One supplies a high-level 10,000 IU serving of superior quality cholecalciferol D3 to compensate for nutritional challenges related to deficiency, lack of sun exposure, and poor absorbability. Vitamin D production is reduced by anything that decreases the intensity of the sun's rays, such as cloud cover, seasons, time of day, smog, use of sunblock, and skin melanin content. There are very few dietary sources of Vitamin D. Fatty fish and fortified milk are the best sources, although these foods may not provide enough Vitamin D. In addition, Vitamin D levels decline with age.

75% of Americans fail to reach recommended daily vitamin D intake, which doubles between ages 51 and 70, and triples over age 71 – making vitamin D supplementation increasingly important as we age. Patient One Vitamin D3 promotes peak bone density and skeletal strength. D3’s ability to promote normal cell growth and metabolism provides additional benefits for cardiovascular, breast, colon, prostate and immune health.

• In a study of 1,739 women with an average age of 59, researchers suggested that moderate to severe vitamin D deficiency is a risk factor for developing cardiovascular problems.
• According to the 2004 Surgeon General’s Report on Bone Health and Osteoporosis: “The Surgeon General wants you to know that you can improve your bone health by getting enough calcium, vitamin D, and physical activity.”
• In a meta-analysis examining five studies measuring serum vitamin D in association with colon health, researchers reported a significant benefit to colon health in those with the highest serum levels of vitamin D3.
• In a meta-analysis of 12 clinical trials totaling over 42,000 adults age 65 and up, researchers found that vitamin D supplementation (at a daily level of 400 international units and above) reduced hip fractures by 18% and reduced non vertebral fractures by 20%.

1. Segal E, Zinman C, Raz B, Ish-Shalom S. Low patient compliance—a major negative factor in achieving vitamin D adequacy in elderly hip fracture patients supplemented with 800IU of vitamin D3 daily. Arch Gerontol Geriatr. 2009 Nov-Dec;49(3):364-7.
2. Wang, TJ, et al. Vitamin D Deficiency and Risk of Cardiovascular Disease. Circulation 2008;117;503-511.
3. Bischoff-Ferrari et al. Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials. Archives of Internal Medicine, 2009; 169 (6): 551 DOI: 10.1001/archinternmed.2008.600
4. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007;167:1730
5. Wang L, Manson JE, Song Y, Sesso HD. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. 2010 Mar 2;152(5):315-23.
6. Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. 2009 Mar 23;169(6):626-32.
7. Baeke F, et al. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010 Aug;10(4):482-96. Epub 2010 Apr 27.
8. Coussens, Anna K., Celeste E. Naude, Rene Goliath, George Chaplin, Robert J. Wilkinson, and Nina G. Jablonski. "High-Dose Vitamin D3 Reduces Deficiency Caused by Low UVB Exposure and Limits HIV-1 Replication in Urban Southern Africans." Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 26 June 2015.
9. Restorff, Cord Von, Heike A. Bischoff-Ferrari, and Robert Theiler. "High-dose Oral Vitamin D3 Supplementation in Rheumatology Patients with Severe Vitamin D3 Deficiency." Bone 45.4 (2009): 747-49.
10. Van Amerongen, Barbara M., and Francois Feron. "Effect of High-Dose Vitamin D3 Intake on Ambulation, Muscular Pain and Bone Mineral Density in a Woman with Multiple Sclerosis: A 10-Year Longitudinal Case Report." International Journal of Molecular Sciences. International Journal of Molecular Sciences, 19 Oct. 2012.
11. Zabul Pitor, et al. "A Proposed Molecular Mechanism of High-dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia." International Journal of Molecular Sciences. International Journal of Molecular Sciences, 9 June 2015.